1-(2,4-Difluorophenyl)-1H-indazol-4-amine → 2-({[1-(2,4-Difluorophenyl)-1h-indazol-4-yl]amino}methyl)-4-(2,3-dihydro-1-benzofuran-7-yl)-1,1,1-trifluoro-4-methyl-2-pentanol

HRID 418798

Reaction equation

HRID 418798 reaction equation
[CH3:1][C:2]([C:12]1[C:20]2[O:19][CH2:18][CH2:17][C:16]=2[CH:15]=[CH:14][CH:13]=1)([CH3:11])[CH2:3][C:4]1([C:7]([F:10])([F:9])[F:8])[CH2:6][O:5]1.[F:21][C:22]1[CH:27]=[C:26]([F:28])[CH:25]=[CH:24][C:23]=1[N:29]1[C:37]2[CH:36]=[CH:35][CH:34]=[C:33]([NH2:38])[C:32]=2[CH:31]=[N:30]1>>[F:21][C:22]1[CH:27]=[C:26]([F:28])[CH:25]=[CH:24][C:23]=1[N:29]1[C:37]2[C:32](=[C:33]([NH:38][CH2:6][C:4]([OH:5])([CH2:3][C:2]([C:12]3[C:20]4[O:19][CH2:18][CH2:17][C:16]=4[CH:15]=[CH:14][CH:13]=3)([CH3:11])[CH3:1])[C:7]([F:8])([F:9])[F:10])[CH:34]=[CH:35][CH:36]=2)[CH:31]=[N:30]1

Participants

3

Reactant 2

HCID 576159631-(2,4-Difluorophenyl)-1H-indazol-4-amine2×HCID 577755187-[1,1-Dimethyl-2-(2-trifluoromethyloxiranyl)ethyl]-2,3-dihydrobenzofuran

Product 1

HCID 576159512-({[1-(2,4-Difluorophenyl)-1h-indazol-4-yl]amino}methyl)-4-(2,3-dihydro-1-benzofuran-7-yl)-1,1,1-trifluoro-4-methyl-2-pentanol

Procedure

Prepared similarly to Example 1 from racemic 7-{1,1-dimethyl-2-[2-(trifluoromethyl)-2-oxiranyl]ethyl}-2,3-dihydro-1-benzofuran (which may be prepared according to WO 04/063163) and 1-(2,4-difluorophenyl)-1H-indazol-4-amine (Intermediate 4).

Sources & evidence

ORD record
ord-fdbfcd9d4b414233a5ad0aa80a0db44e
Source dataset
uspto-grants-2012_01
Patent number
US08093281B2

Linked notes

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