C[O:2][C:3]1[CH:4]=[C:5]2[C:14](=[CH:15][CH:16]=1)[CH2:13][CH:12]([C:17]1[CH:22]=[CH:21][C:20]([O:23]C)=[CH:19][CH:18]=1)[CH:11]1[CH:6]2[CH2:7][CH2:8][CH2:9][CH2:10]1.C(Cl)Cl.B(Br)(Br)Br>C(OCC)(=O)C>[OH:23][C:20]1[CH:19]=[CH:18][C:17]([CH:12]2[CH2:13][C:14]3[CH:15]=[CH:16][C:3]([OH:2])=[CH:4][C:5]=3[CH:6]3[CH:11]2[CH2:10][CH2:9][CH2:8][CH2:7]3)=[CH:22][CH:21]=1Combine 6-methoxy-10-(4-methoxy-phenyl)-1,2,3,4,4a,9,10,10a-octahydro-phenanthrene (132.1 mg, 0.41 mmol), methylene chloride (4.0 mL), boron tribromide (0.16 mL, 1.64 mmol) at 0° C., and stir under a nitrogen atmosphere. After 1.5 hours, add ethyl acetate to reaction mixture, quench reaction with sat ammonium chloride solution (aq). Wash organic layer with brine, dry over sodium sulfate, and concentrate in vacuo. Flash chromatograph to yield the titled compound (86.7 mg, 72%) as a white solid. 1H NMR (DMSO): 9.15 (s, 1H), 9.00 (s, 1H), 7.08 (d, 2H, J=8.8 Hz), 6.93 (d, 1H, J=8.4 Hz), 6.70 (m, 3H), 6.52 (dd, 1H, J=8.4, 2.2 Hz), 3.05 (m, 3H), 2.65 (m, 1H), 2.34 (d, 1H, J=12.8 Hz), 1.88 (m, 1H), 1.55 (m, 2H), 1.37 (m, 1H), 1.05 (m, 4H); MS m/z 293 (M−1).
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