Phosphorus oxybromide → 2,3-Dibromo-5-nitropyridine

Participants

Reaction Conditions

Reaction Steps

A mixture of 3-bromo-5-nitropyridin-2-ol, POBr3 and PBr3 was heated at 120° C. for 3.5 h. The crude mixture was poured into a mixture of ice and water and extracted with DCM. The crude mixture was purified by flash chromatography over SiO2 eluting with hexane/ethyl acetate mixtures affording 2.63 g (yield 73%) of the expected product.

Provenance & Evidence