反应详情

温度

120 °C

A mixture of 3-bromo-5-nitropyridin-2-ol, POBr3 and PBr3 was heated at 120° C. for 3.5 h. The crude mixture was poured into a mixture of ice and water and extracted with DCM. The crude mixture was purified by flash chromatography over SiO2 eluting with hexane/ethyl acetate mixtures affording 2.63 g (yield 73%) of the expected product.

1. extractionextracted with DCM
2. customThe crude mixture was purified by flash chromatography over SiO2 eluting with hexane/ethyl acetate