2,5-Dibromo-3-methylpyridine → 5-Bromo-2-(3-ethoxyphenyl)-3-methylpyridine

HRID 42015

Reaction equation

HRID 42015 reaction equation
Br[C:2]1[C:7]([CH3:8])=[CH:6][C:5]([Br:9])=[CH:4][N:3]=1.[CH2:10]([O:12][C:13]1[CH:14]=[C:15](B(O)O)[CH:16]=[CH:17][CH:18]=1)[CH3:11]>>[Br:9][C:5]1[CH:6]=[C:7]([CH3:8])[C:2]([C:17]2[CH:16]=[CH:15][CH:14]=[C:13]([O:12][CH2:10][CH3:11])[CH:18]=2)=[N:3][CH:4]=1

Participants

3

Reactant 2

HCID 8176802,5-Dibromo-3-methylpyridineHCID 27739203-Ethoxybenzeneboronic acid

Product 1

HCID 584157605-Bromo-2-(3-ethoxyphenyl)-3-methylpyridineYield 37%

Procedure

Obtained (1.30 g, yield 37%) following the procedure described in Intermediate 27, starting with 2,5-dibromo-3-methylpyridine (11.96 mmol, 3.0 g), 3-ethoxyphenylboronic acid (11.96 mmol, 1.98 g).

Workup

  1. customObtained (1.30 g, yield 37%)

Sources & evidence

ORD record
ord-33a4b93db77a4bf6a6afdfbf2888e006
Source dataset
uspto-grants-2013_09
Patent number
US08536165B2

Linked notes

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