Isopropyl Myristate → Olopatadine

HRID 422887

Reaction equation

HRID 422887 reaction equation
[CH3:1][N:2]([CH2:4][CH2:5]/[CH:6]=[C:7]1/[C:8]2[CH:9]=[CH:10][CH:11]=[CH:12][C:13]=2[CH2:14][O:15][C:16]2[CH:21]=[CH:20][C:19]([CH2:22][C:23]([OH:25])=[O:24])=[CH:18][C:17]/1=2)[CH3:3].Cl.C(OCC)(=O)C.C(OC(C)C)(=O)CCCCCCCCCCCCC.C([O-])(=O)C=C>C1(C)C=CC=CC=1.C(OCC)(=O)C.C1(C)C=CC=CC=1>[CH3:1][N:2]([CH2:4][CH2:5]/[CH:6]=[C:7]1/[C:8]2[CH:9]=[CH:10][CH:11]=[CH:12][C:13]=2[CH2:14][O:15][C:16]2[CH:21]=[CH:20][C:19]([CH2:22][C:23]([OH:25])=[O:24])=[CH:18][C:17]/1=2)[CH3:3]

Participants

7

Reactant 4

HCID 8042Isopropyl MyristateHCID 8857Ethyl AcetateHCID 25188AcrylateHCID 5282402Olopatadine Hydrochloride3×

Product 1

HCID 5281071Olopatadine

Reagents, catalysts & solvents 2

HCID 1140TolueneSolventHCID 21584019Toluene ethylacetateSolvent

Procedure

The obtained olopatadine hydrochloride was mixed with about 2 mL of ethyl acetate. The mixture was subjected to ultrasonication in disposable cup for about 30 seconds in order to dissolve or disperse olopatadine hydrochloride, and fully mixed with isopropyl myristate. Acrylic pressure sensitive adhesive 3.7125 g (PE-300; acrylate copolymer; solid content of 40% by weight (ethyl acetate/toluene mixed solvent): 1.485 g; Nippon Carbide Industries Co., Ltd.) and crosslinking agent 0.015 g (CK401; metal chelate; solid content of about 10% by weight (toluene solvent): 0.0015 g; Nippon Carbide Industries Co., Ltd.) were sequentially added to the mixture. The mixture was fully mixed and degassed. The mixture was spread over release liner using metering knife or baker applicator, and stood until the organic solvent was completely evaporated. Subsequently, support was laid over the release liner and compressed using roller, and subjected to crosslinking in temperature controlled bath for 8 to 12 hours at about 40° C. to give adhesive preparation comprising olopatadine hydrochloride.

Workup

  1. customThe mixture was subjected to ultrasonication in disposable cup for about 30 seconds in order
  2. dissolutionto dissolve
  3. additionwere sequentially added to the mixture
  4. additionThe mixture was fully mixed
  5. customdegassed
  6. customwas completely evaporated
  7. customfor 8 to 12 hours
  8. customat about 40° C.
  9. customto give adhesive
  10. custompreparation

Sources & evidence

ORD record
ord-b9a3d724850f4afbb87c2eecafd1c602
Source dataset
uspto-grants-2012_01
Patent number
US08101654B2

Linked notes

Loading…