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Potassium Chloride → 2,8-Dibenzyl-3-methoxy-6-phenyl-imidazo[1,2-a]pyrazine

HRID 424458
Notes
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Reaction equation

HRID 424458 reaction equation
[CH:1]1[CH:2]=[CH:3][C:4]([CH2:7][C:8]2[C:9]3[N:13]([CH:14]=[C:15]([C:17]4[CH:18]=[CH:19][C:20](O)=[CH:21][CH:22]=4)[N:16]=2)[C:12]([OH:24])=[C:11]([CH2:25][C:26]2[CH:27]=[CH:28][C:29](O)=[CH:30][CH:31]=2)[N:10]=3)=[CH:5][CH:6]=1.[CH2:33]1N(CCO)CCN(CCS(O)(=O)=O)C1.[Cl-].[K+].C(N(CC(O)=O)CC(O)=O)CN(CC(O)=O)CC(O)=O.CCC(COC(C(N(CC[NH+](C)C)C)=O)(C1C=CC=CC=1)C1C=CC=CC=1)CC.[Cl-]>OCC(CO)O>[CH2:25]([C:11]1[N:10]=[C:9]2[C:8]([CH2:7][C:4]3[CH:5]=[CH:6][CH:1]=[CH:2][CH:3]=3)=[N:16][C:15]([C:17]3[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=3)=[CH:14][N:13]2[C:12]=1[O:24][CH3:33])[C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1
ParticipantsProcedureSources & evidenceReaction notes

Participants

7

Reactant 5

HCID 4873Potassium ChlorideHCID 6049Ethylenediaminetetraacetic AcidHCID 19153X 100HCID 238314-(2-Hydroxyethyl)-1-piperazineethanesulfonic acidHCID 135445694Coelenterazine4×

Product 1

HCID 66702735
2,8-Dibenzyl-3-methoxy-6-phenyl-imidazo[1,2-a]pyrazine

Reagents, catalysts & solvents 1

HCID 753GlycerolSolvent

Procedure

Chemiluminescence of P450 altered coelenterazine or coelenterazine derivatives was determined immediately following addition of 80 microliter of 37.5 mM Hepes pH7.4; 625 mM KCl; 0.125 mM EDTA pH 8.0; 0.25% Triton X-100; 0.125% Mazu; 1.25% Glycerol; 0.25 mg/mL gelatin to the P450 reactions. Renilla luciferase (1.2 ng/mL) (purchased from Chemicon) was added for detection of bioluminescence of P450 altered coelenterazine or coelenterazine derivatives.

Sources & evidence

ORD record
ord-535ac1a8fe8f44c28e3893af634bb01b
Source dataset
uspto-grants-2012_01
DOI
10.6084/m9.figshare.5104873.v1
Patent number
US08106052B2

Reaction notes

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On this pageParticipantsProcedureSources & evidenceReaction notes