Acetonitrile → HCID 672273, compound
Reaction equation
[OH-].[K+].[NH2:3][C:4]1[CH:17]=[CH:16][C:15]([Cl:18])=[CH:14][C:5]=1[C:6]([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)=O.C(OCC)(=O)C.[C:25](#[N:27])[CH3:26]>>[NH2:27][C:25]1[CH:26]=[C:6]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)[C:5]2[C:4](=[CH:17][CH:16]=[C:15]([Cl:18])[CH:14]=2)[N:3]=1Participants
5
Procedure
A suspension of 1.4 g of powdered KOH in 25 ml of anhydrous acetonitrile stirred under an argon atmosphere was heated to boiling under reflux conditions for 30 minutes and then a solution of 1.15 g of 2-amino-5-chlorobenzophenone in 5 ml of anhydrous acetonitrile was added. The mixture was boiled with a reflux condenser for 12 hours. Cooling was followed by pouring into ice, extraction with ethyl acetate, washing with water and removal of the solvent by distillation.