Pyridine → HCID 66703605, compound

HRID 425985

Reaction equation

HRID 425985 reaction equation
[F:1][C:2]1[CH:10]=[C:9]([C:11]([F:14])([F:13])[F:12])[CH:8]=[CH:7][C:3]=1[C:4](Cl)=[O:5].N1C=CC=CC=1.[NH2:21][C:22]1[CH:31]=[C:30]2[C:25]([CH2:26][CH2:27][C:28](=[O:33])[N:29]2[CH3:32])=[CH:24][CH:23]=1>O>[F:1][C:2]1[CH:10]=[C:9]([C:11]([F:14])([F:13])[F:12])[CH:8]=[CH:7][C:3]=1[C:4]([NH:21][C:22]1[CH:31]=[C:30]2[C:25]([CH2:26][CH2:27][C:28](=[O:33])[N:29]2[CH3:32])=[CH:24][CH:23]=1)=[O:5]

Participants

5

Reactant 3

HCID 1049PyridineHCID 1455802-Fluoro-4-(trifluoromethyl)benzoyl chlorideHCID 33699394HCID 33699394, compound

Product 1

HCID 66703605HCID 66703605, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

2-Fluoro-4-(trifluoromethyl)benzoyl chloride was added to a pyridine solution of 7-amino-1-methyl-3,4-dihydroquinolin-2(1H)-one, followed by stirring at room temperature for 12 hours. Water was added to the reaction liquid, followed by stirring for 30 minutes and then the precipitated crystals were collected by filtration to obtain 2-fluoro-N-(1-methyl-2-oxo-1,2,3,4-tetrahydroquinolin-7-yl)-4-(trifluoromethyl)benzamide.

Workup

  1. stirringby stirring for 30 minutes
  2. filtrationthe precipitated crystals were collected by filtration

Sources & evidence

ORD record
ord-37e90418f05547b9ae14e3e6437759f8
Source dataset
uspto-grants-2012_01
Patent number
US08106190B2

Linked notes

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