1,3-Dimethyl 2-(4-bromo-2-nitrophenyl)propanedioate → 4-Bromo-2-nitrophenylacetic Acid
Reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8](C(OC)=O)[C:9]([O:11]C)=[O:10])=[C:4]([N+:17]([O-:19])=[O:18])[CH:3]=1>Cl>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][C:9]([OH:11])=[O:10])=[C:4]([N+:17]([O-:19])=[O:18])[CH:3]=1Participants
3
Reactant 1
Product 1
Reagents, catalysts & solvents 1
Procedure
Crude dimethyl 4-bromo-2-nitrophenylmalonate was heated at 110° C. in 40 mL of 6N hydrochloric acid for 24 hours and then cooled. The precipitate was collected by filtration, washed with water and dried to give 5.3 g (89% yield) of 4-bromo-2-nitrophenylacetic acid as an off white solid.
Workup
- temperaturecooled
- filtrationThe precipitate was collected by filtration
- washwashed with water
- customdried
Sources & evidence
- ORD record
- ord-7465f6374dc54cc780d29ecbb9ef2218
- Source dataset
- uspto-grants-2001_11
- Patent number
- US06316429B1
Reaction notes
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