tert-Butyl methyl ether → HCID 178435105, compound

HRID 429786

Reaction equation

HRID 429786 reaction equation
[CH3:1][C:2]1[N:3]=[CH:4][S:5][C:6]=1[CH3:7].[Br:8]CC([C:12]1[S:13][CH:14]=[CH:15][CH:16]=1)=O.C[O:18][C:19](C)(C)[CH3:20]>C(O)C>[Br-:8].[SH:13]1([C:19](=[O:18])[CH2:20][N+:3]2[C:2]([CH3:1])=[C:6]([CH3:7])[S:5][CH:4]=2)[CH:12]=[CH:16][CH:15]=[CH:14]1

Participants

5

Reactant 3

HCID 15413tert-Butyl methyl etherHCID 625104,5-DimethylthiazoleHCID 27763722-Bromo-1-(thiophen-2-yl)ethan-1-one

Product 1

HCID 178435105HCID 178435105, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of 4,5-dimethylthiazole (2,2 g, 19.4 mmol) and 2-bromoacetylthiophene (4 g, 19.4 mmol) in ethyl alcohol (20 mL) was refluxed for 3 hours. It was cooled to room temperature and t-butyl methyl ether (10 mL) was added. The reaction mixture was left at room temperature overnight with stirring. The white product separated and was filtered and dried. It was crystallized from ethyl alcohol (4.42 g, 73%), m.p. 203-205° C.

Workup

  1. customThe white product separated
  2. filtrationwas filtered
  3. customdried
  4. customIt was crystallized from ethyl alcohol (4.42 g, 73%), m.p. 203-205° C.

Sources & evidence

ORD record
ord-07544ed515c34ce68a593ce274f675ff
Source dataset
uspto-grants-2001_11
Patent number
US06319934B1

Linked notes

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