Chlorine → HCID 12445115, compound
Reaction equation
[Cl:1]Cl.[CH3:3][C:4]1[CH:8]([CH3:9])[C:7](=[O:10])[NH:6][N:5]=1>ClCCCl>[CH3:3][C:4]1[C:8]([CH3:9])([Cl:1])[C:7](=[O:10])[NH:6][N:5]=1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
A chlorine gas was introduced into a solution of 3,4-dimethyl-2-pyrazolin-5-one in 1,2-dichloroethane, followed by gradual refluxing. After the reaction, the reaction mixture was cooled and filtered. The solvent was then distilled off. The residue in the form of an oil was recrystallized from a 1:1 mixture of benzene and petroleum ether, whereby 3,4-dimethyl-4-chloro-2-pyrazolin-5-one was obtained.
Workup
- customAfter the reaction
- temperaturethe reaction mixture was cooled
- filtrationfiltered
- distillationThe solvent was then distilled off
- customThe residue in the form of an oil was recrystallized from a 1:1 mixture of benzene and petroleum ether
Sources & evidence
- ORD record
- ord-4f8625b4746547ac91aeb5c618a5af54
- Source dataset
- uspto-grants-2001_11
- Patent number
- US06322908B1
Reaction notes
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