Acetic Anhydride → 5-Acetamido-phthalide

HRID 430468

Reaction equation

HRID 430468 reaction equation
[NH2:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[C:7](=[O:8])[O:6][CH2:5]2.[C:12](OC(=O)C)(=[O:14])[CH3:13]>O1CCCC1>[C:12]([NH:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[C:7](=[O:8])[O:6][CH2:5]2)(=[O:14])[CH3:13]

Participants

4

Reactant 2

HCID 7918Acetic AnhydrideHCID 7206695-Aminophthalide

Product 1

HCID 5909685-Acetamido-phthalide

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

3 g of 5-amino-phthalide, 10 ml of acetic anhydride and 30 ml of tetrahydrofuran are refluxed for 1 hour. The crystals that are precipitated after cooling are suctioned off and washed with isopropylether. 3.3 g of the title compound is obtained, flash point >300° C.

Workup

  1. customThe crystals that are precipitated
  2. temperatureafter cooling
  3. washwashed with isopropylether

Sources & evidence

ORD record
ord-1310c23c3ad54c2b9f9a571c78bfeef0
Source dataset
uspto-grants-2001_11
Patent number
US06323199B1

Linked notes

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