Tetrahydrothiophene → Methyl-tetrahydrothiophene triflate

HRID 43294

Reaction equation

HRID 43294 reaction equation
[S:1]1[CH2:5][CH2:4][CH2:3][CH2:2]1.[CH3:6][O:7][S:8]([C:11]([F:14])([F:13])[F:12])(=[O:10])=[O:9]>ClCCl>[OH:10][S:8]([C:11]([F:14])([F:13])[F:12])(=[O:9])=[O:7].[CH3:6][CH:2]1[CH2:3][CH2:4][CH2:5][S:1]1

Participants

4

Reactant 2

HCID 1127TetrahydrothiopheneHCID 9526Methyl triflate

Product 1

HCID 87659244Methyl-tetrahydrothiophene triflate

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

11 mmol of tetrahydrothiophene was dissolved in 10 ml of dichloromethane at 0° C., and about 12 mmol of methyltrifluoromethane sulfonate was slowly dripped to the mixture. As a result, a white solid product in a salt form was obtained after about 5 minutes. The solid product was filtered and dried for 1 hour in an oven at 50° C. to obtain the following product:

Workup

  1. customAs a result, a white solid product in a salt form was obtained after about 5 minutes
  2. filtrationThe solid product was filtered
  3. customdried for 1 hour in an oven at 50° C.
  4. customto obtain the following product

Sources & evidence

ORD record
ord-9dffcd1064074e23ac42b75b8afab9eb
Source dataset
uspto-grants-2013_09
Patent number
US08536347B2

Linked notes

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