4-Cyanophenol → tert-Butyl 4-(4-cyanophenoxy)piperidine-1-carboxylate

HRID 43351

Reaction equation

HRID 43351 reaction equation
[OH:1][C:2]1[CH:9]=[CH:8][C:5]([C:6]#[N:7])=[CH:4][CH:3]=1.O[CH:11]1[CH2:16][CH2:15][N:14]([C:17]([O:19][C:20]([CH3:23])([CH3:22])[CH3:21])=[O:18])[CH2:13][CH2:12]1>>[C:6]([C:5]1[CH:8]=[CH:9][C:2]([O:1][CH:11]2[CH2:16][CH2:15][N:14]([C:17]([O:19][C:20]([CH3:23])([CH3:22])[CH3:21])=[O:18])[CH2:13][CH2:12]2)=[CH:3][CH:4]=1)#[N:7]

Participants

3

Reactant 2

HCID 130194-CyanophenolHCID 643502Tert-butyl 4-hydroxypiperidine-1-carboxylate

Product 1

HCID 23019443tert-Butyl 4-(4-cyanophenoxy)piperidine-1-carboxylate

Procedure

The title compound was prepared from 4-hydroxybenzonitrile and 1,1-dimethylethyl 4-hydroxy-1-piperidinecarboxylate using a method similar to that described for D13.

Sources & evidence

ORD record
ord-bd52ff07ce2943018d46f87fab6db575
Source dataset
uspto-grants-2013_09
Patent number
US08536182B2

Linked notes

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