Lithium Hydroxide → cis(+/-)-2-(4-{[(4,5-Diiodo-1H-imidazol-2-yl)carbonyl]amino}-3-methoxypiperidin-1-yl)-4-methyl-1,3-thiazole-5-carboxylic acid
Reaction equation
[I:1][C:2]1[N:3]=[C:4]([C:8]([NH:10][C@H:11]2[CH2:16][CH2:15][N:14]([C:17]3[S:18][C:19]([C:23]([O:25]CC)=[O:24])=[C:20]([CH3:22])[N:21]=3)[CH2:13][C@H:12]2[O:28][CH3:29])=[O:9])[NH:5][C:6]=1[I:7].[OH-].[Li+]>>[I:1][C:2]1[N:3]=[C:4]([C:8]([NH:10][C@H:11]2[CH2:16][CH2:15][N:14]([C:17]3[S:18][C:19]([C:23]([OH:25])=[O:24])=[C:20]([CH3:22])[N:21]=3)[CH2:13][C@H:12]2[O:28][CH3:29])=[O:9])[NH:5][C:6]=1[I:7]Participants
3
Procedure
The same operation as in Example (1i) was performed using ethyl cis(±)-2-(4-{[(4,5-diiodo-1H-imidazol-2-yl)carbonyl]amino}-3-methoxypiperidin-1-yl)-4-methyl-1,3-thiazole-5-carboxylate obtained in Example (71d) (83 mg, 0.13 mmol) and 2 N lithium hydroxide (2 mL), to obtain 66.9 mg of the title compound as a white solid (84%).
Sources & evidence
- ORD record
- ord-0e1232186ef6472db07eaacbcaa0547c