HCID 54682948, compound → 4-Hydroxy-5,6,7,8-tetrahydroquinolin-2(1H)-one
Reaction equation
C([C:6]1[C:7](=[O:17])[NH:8][C:9]2[CH2:10][CH2:11][CH2:12][CH2:13][C:14]=2[C:15]=1[OH:16])(OCC)=O>Cl>[OH:16][C:15]1[C:14]2[CH2:13][CH2:12][CH2:11][CH2:10][C:9]=2[NH:8][C:7](=[O:17])[CH:6]=1Participants
3
Reactant 1
Product 1
Reagents, catalysts & solvents 1
Procedure
A suspension of 3-carboethoxy-4-hydroxy-5,6,7,8-tetrahydrocarbostyril (19.4g; 0.082 mole) in 2N hydrochloric acid (200 ml) was refluxed 30 hrs. and the clear solution evaporated to dryness. Water was added and the solution brought to pH 4.0 with dilute sodium hydroxide solution. The precipitated white product was filtered off, washed well with water and recrystallised from glacial acetic acid, m.p. >330° C.
Workup
- temperaturewas refluxed 30 hrs
- customand the clear solution evaporated to dryness
- additionWater was added
- filtrationThe precipitated white product was filtered off
- washwashed well with water
- customrecrystallised from glacial acetic acid, m.p. >330° C.
Sources & evidence
- ORD record
- ord-87153620a16f423b9e337ec162c2cc37
- Source dataset
- uspto-grants-1977_02
- Patent number
- US04006237
Reaction notes
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