1-Bromo-3-chloropropane → HCID 21429013, compound
Reaction equation
[S:1]1[CH2:6][CH2:5][CH2:4][NH:3][C:2]1=[S:7].[Br:8][CH2:9][CH2:10][CH2:11]Cl>C(O)C>[Br-:8].[S:1]1[C:2]2[S:7][CH2:9][CH2:10][CH2:11][N+:3]=2[CH2:4][CH2:5][CH2:6]1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
A mixture of 66.5 g. of tetrahydro-1,3-thiazin-2-thione and 83 g. of 1-bromo-3-chloropropane in 200 ml. of ethanol is refluxed for 24 hours. The solvent is removed under vacuum and the residue triturated with ether, then acetone. The product is recrystallized from ethanol yielding 2,3,6,7-tetrahydro-(1,3)-thiazino-[2,3-b]-(1,3)-thiazinium bromide.
Workup
- additionA mixture of 66.5 g
- customThe solvent is removed under vacuum
- customthe residue triturated with ether
- customThe product is recrystallized from ethanol
Sources & evidence
- ORD record
- ord-36dfba97b29146dea05ec5f3061535bc
- Source dataset
- uspto-grants-1977_06
- Patent number
- US04031228
Reaction notes
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