Vidarabine → Vidarabine

HRID 439284

Reaction equation

HRID 439284 reaction equation
[CH:1]1[N:5]([CH2:6][O:7][CH2:8][CH2:9][OH:10])[C:4]2[N:11]=[C:12]([NH2:16])[N:13]=[C:14]([OH:15])[C:3]=2[N:2]=1.[C@@H:17]1([N:26]2[CH:34]=[N:33][C:32]3[C:27]2=[N:28][CH:29]=[N:30][C:31]=3[NH2:35])[O:23][C@H:22]([CH2:24][OH:25])[C@@H:20]([OH:21])[C@@H:18]1[OH:19].C([O-])(O)=O.[Na+].C[C@@H](NC)[C@H]1O[C@H](O[C@H]2[C@H](O)[C@@H](O[C@H]3OC[C@@](O)(C)[C@H]([NH:66]C)[C@H]3O)[C@H](N)C[C@@H]2N)[C@H](N)CC1>>[CH:1]1[N:5]([C@@H:6]2[O:7][C@H:8]([CH2:9][OH:10])[C@@H:18]([OH:19])[C@H:17]2[OH:23])[N:66]=[C:3]([C:14]([NH2:13])=[O:15])[N:2]=1.[CH:1]1[N:5]([CH2:6][O:7][CH2:8][CH2:9][OH:10])[C:4]2[N:11]=[C:12]([NH2:16])[N:13]=[C:14]([OH:15])[C:3]=2[N:2]=1.[C@@H:17]1([N:26]2[CH:34]=[N:33][C:32]3[C:27]2=[N:28][CH:29]=[N:30][C:31]=3[NH2:35])[O:23][C@H:22]([CH2:24][OH:25])[C@@H:20]([OH:21])[C@@H:18]1[OH:19]

Participants

7

Reactant 4

HCID 21704VidarabineHCID 72395Gentamicin C1HCID 516892Sodium BicarbonateHCID 178508933HCID 178508933, compound

Product 3

HCID 21704VidarabineHCID 37542RibavirinHCID 178508933HCID 178508933, compound

Procedure

Ribavirin was obtained from ICN Pharmaceuticals, Costa Mesa, Calif. Acyclovir and 9β-D-arabinofuranosyladenine (ara-A) were purchased from Sigma Chemical Co., St. Louis, Mo. Ribavirin, acyclovir and ara-A were prepared and diluted in MEM without serum, plus 0.18% NaHCO3, 50 μg gentamicin/ml. Oligonucleotides were diluted in the same solution.

Sources & evidence

ORD record
ord-4b6177f3306a4b0cbc3ac38f9b4621ab
Source dataset
uspto-grants-1996_05
Patent number
US05514577

Linked notes

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