Hydrochloric Acid → HCID 21473349, compound

HRID 440247

Reaction equation

HRID 440247 reaction equation
C(OC([N:8]1[CH2:12][CH:11]([NH:13][C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[CH:10]([OH:20])[CH2:9]1)=O)(C)(C)C.[ClH:21]>CO>[ClH:21].[OH:20][CH:10]1[CH:11]([NH:13][C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[CH2:12][NH:8][CH2:9]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 214733471-t-Butoxycarbonyl-3-hydroxy-4-phenylaminopyrrolidine

Product 1

HCID 21473349HCID 21473349, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

In 100 ml of methanol was dissolved 2.4 g (0.0086 mole) of 1-t-butoxycarbonyl-3-hydroxy-4-phenylaminopyrrolidine obtained as described above, and 30 ml of 6N hydrochloric acid was added thereto. After the mixture was refluxed by heating for 2.5 hours, the solvent was removed under reduced pressure. The resulting residue was washed with ethanol and ether to obtain 1.52 g of 3-hydroxy-4-phenylaminopyrrolidine hydrochloride as light brown powder.

Workup

  1. customobtained
  2. additionwas added
  3. temperatureAfter the mixture was refluxed
  4. temperatureby heating for 2.5 hours
  5. customthe solvent was removed under reduced pressure
  6. washThe resulting residue was washed with ethanol and ether

Sources & evidence

ORD record
ord-a89ab264fdd34f32a615651710c675eb
Source dataset
uspto-grants-1996_05
Patent number
US05519016

Linked notes

Loading…