Acetone → HCID 178444015, compound

HRID 441336

Reaction equation

HRID 441336 reaction equation
[Na].CC(C)=O.Cl.[C:7]([NH2:15])(=[NH:14])[CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH3:13].[Cl:16][C:17]1[CH:22]=[C:21]([CH3:23])[CH:20]=[CH:19][C:18]=1[N:24]=[C:25]=[S:26]>C1C=CC=CC=1.CCCCC>[Cl:16][C:17]1[CH:22]=[C:21]([CH3:23])[CH:20]=[CH:19][C:18]=1[NH:24][C:25]([NH:14][C:7](=[NH:15])[CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH3:13])=[S:26]

Participants

6

Reactant 4

HCID 180Acetone2×HCID 1435292-Chloro-4-methylphenyl isothiocyanateHCID 5360545SodiumHCID 14144282Heptanimidamide hydrochloride

Product 1

HCID 178444015HCID 178444015, compound

Reagents, catalysts & solvents 1

HCID 19707280Benzene n-pentaneSolvent

Procedure

Following a procedure similar to that described in Example 1 and using 2.3 g. sodium in 250 ml. dry acetone, 16.4 g. heptanamidine hydrochloride, and 16 g. 2-chloro-4-methylphenyl isothiocyanate (b.p. 80°-82° C./0.3 mm.; prepared from 2-chloro-4-methylaniline) in 100 ml. dry acetone there was obtained 1-(2-chloro-4-methylphenyl)-3-(heptanimidoyl)-2-thiourea, m.p. 78°-80° C. (from benzene-n-pentane); hydrochloride (23 g.), m.p. 138°-140° C. (from isopropyl alcohol).

Sources & evidence

ORD record
ord-79d54b055f0c443c9912ce0a682bb07b
Source dataset
uspto-grants-1977_08
Patent number
US04039575

Linked notes

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