Phenolate Sodium → 2-Amino-3-morpholino-5-phenoxypyrazine

HRID 441753

Reaction equation

HRID 441753 reaction equation
[O-:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[Na+].[NH2:9][C:10]1[CH:15]([N:16]2[CH2:21][CH2:20][O:19][CH2:18][CH2:17]2)[N:14](Br)[CH:13]=[CH:12][N:11]=1>>[NH2:9][C:10]1[C:15]([N:16]2[CH2:17][CH2:18][O:19][CH2:20][CH2:21]2)=[N:14][C:13]([O:1][C:2]2[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=2)=[CH:12][N:11]=1

Participants

3

Reactant 2

HCID 4445035Phenolate SodiumHCID 536932332-Amino-3-morpholino-4-bromopyrazine

Product 1

HCID 205289482-Amino-3-morpholino-5-phenoxypyrazine

Procedure

A suspension of 0.1 mole of sodium phenoxide and 0.1 mole of 2-amino-3-morpholino-4-bromopyrazine is refluxed 10- 20 hours. The cooled mixture is extracted with diethyl ether, washed with cold 2N sodium hydroxide solution, dried and evaporated to give 2-amino-3-morpholino-5-phenoxypyrazine.

Workup

  1. temperatureis refluxed 10- 20 hours
  2. extractionThe cooled mixture is extracted with diethyl ether
  3. washwashed with cold 2N sodium hydroxide solution
  4. customdried
  5. customevaporated

Sources & evidence

ORD record
ord-eb7cf89b95704585b431a99c17c81cc5
Source dataset
uspto-grants-1977_08
Patent number
US04042586

Linked notes

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