2-Chloro-N-(4-methylphenyl)acetamide → 4-p-Methylanilinocarbonylmethylamino-1-(4-phenyl-4-oxobutyl) piperidine

HRID 442483

Reaction equation

HRID 442483 reaction equation
[NH2:1][CH:2]1[CH2:7][CH2:6][N:5]([CH2:8][CH2:9][CH2:10][C:11]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)=[O:12])[CH2:4][CH2:3]1.[C:19]1([CH3:30])[CH:24]=[CH:23][C:22]([NH:25][C:26](=[O:29])[CH2:27]Cl)=[CH:21][CH:20]=1>>[CH3:30][C:19]1[CH:24]=[CH:23][C:22]([NH:25][C:26]([CH2:27][NH:1][CH:2]2[CH2:7][CH2:6][N:5]([CH2:8][CH2:9][CH2:10][C:11]([C:13]3[CH:14]=[CH:15][CH:16]=[CH:17][CH:18]=3)=[O:12])[CH2:4][CH2:3]2)=[O:29])=[CH:21][CH:20]=1

Participants

3

Reactant 2

HCID 279672-Chloro-N-(4-methylphenyl)acetamideHCID 126085374-Amino-1-(4-phenyl-4-oxobutyl)piperidine

Product 1

HCID 544747764-p-Methylanilinocarbonylmethylamino-1-(4-phenyl-4-oxobutyl) piperidine

Procedure

Using a procedure analogous to Example 1 4-amino-1-(4-phenyl-4-oxobutyl) piperidine may be reacted with N-(p-tolyl) chloro-acetamide to give the title compound.

Sources & evidence

ORD record
ord-06c24b2136434725bd3aa472040ca60e
Source dataset
uspto-grants-1977_08
Patent number
US04045566

Linked notes

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