Methylamine → 1,2,2,2-tetrachloroethyl N-methylcarbamate

HRID 4430

Reaction equation

HRID 4430 reaction equation
[CH3:1][NH2:2].Cl[C:4]([O:6][CH:7]([Cl:12])[C:8]([Cl:11])([Cl:10])[Cl:9])=[O:5]>ClCCl>[CH3:1][NH:2][C:4](=[O:5])[O:6][CH:7]([Cl:12])[C:8]([Cl:11])([Cl:10])[Cl:9]

Participants

4

Reactant 2

HCID 6329MethylamineHCID 27333271,2,2,2-Tetrachloroethyl chloroformate

Product 1

HCID 100373261,2,2,2-tetrachloroethyl N-methylcarbamate

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

34.7 ml (0.4 mmol) of methylamine (in 40% strength aqueous solution) are added dropwise to a solution maintained at 0° C. of 49.4 g (0.2 mole) of 1,2,2,2-tetrachloroethyl chloroformate in dichloromethane (150 ml). The mixture is then stirred for 2 hours at room temperature. The organic phase is washed with 2×100 ml of water and dried over magnesium sulphate.

Workup

  1. washThe organic phase is washed with 2×100 ml of water
  2. dry with materialdried over magnesium sulphate

Sources & evidence

ORD record
ord-15c439ed99fb49c6bfd27dedef4a3286
Source dataset
uspto-grants-1988_02
Patent number
US04725680

Linked notes

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