Sodium Bicarbonate → Prisotinol
Reaction equation
Cl.Cl.[CH:3]([NH:6][CH:7]([CH3:16])[CH2:8][C:9]1[CH:14]=[CH:13][C:12]([OH:15])=[CH:11][N:10]=1)([CH3:5])[CH3:4].C(=O)(O)[O-].[Na+]>O>[CH:3]([NH:6][CH:7]([CH3:16])[CH2:8][C:9]1[CH:14]=[CH:13][C:12]([OH:15])=[CH:11][N:10]=1)([CH3:5])[CH3:4]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
To the solution of 159 g of 2-(2-isopropylaminopropyl)-5-pyridinol dihydrochloride in 1,000 ml of water, 163 g of sodium bicarbonate are added and the suspension evaporated. The residue is suspended in 453 ml of anhydrous ethanol at 60°, the suspension is filtered, the residue washed 3 times with 150 ml of anhydrous ethanol each and the combined filtrates are evaporated, to yield the 2-(2-isopropylaminopropyl)-5-pyridinol melting at 135°-138°.
Workup
- customthe suspension evaporated
- customis suspended in 453 ml of anhydrous ethanol at 60°
- filtrationthe suspension is filtered
- washthe residue washed 3 times with 150 ml of anhydrous ethanol each and the combined filtrates
- customare evaporated
Sources & evidence
- ORD record
- ord-22c50b32e8794b248244640aa0206105
- Source dataset
- uspto-grants-1981_04
- Patent number
- US04260619
Reaction notes
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