Benzoyl isocyanate → N-(3-Cyano-5-methylthiophen-2-ylcarbamoyl)benzamide

HRID 44342

Reaction equation

HRID 44342 reaction equation
[NH2:1][C:2]1[S:3][C:4]([CH3:9])=[CH:5][C:6]=1[C:7]#[N:8].[C:10]([N:18]=[C:19]=[O:20])(=[O:17])[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1>>[C:7]([C:6]1[CH:5]=[C:4]([CH3:9])[S:3][C:2]=1[NH:1][C:19]([NH:18][C:10](=[O:17])[C:11]1[CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=1)=[O:20])#[N:8]

Participants

3

Reactant 2

HCID 78210Benzoyl isocyanateHCID 6890562-Amino-5-methyl-3-thiophenecarbonitrile

Product 1

HCID 57456905N-(3-Cyano-5-methylthiophen-2-ylcarbamoyl)benzamide

Procedure

Prepared as in Example 1a from 2-amino-5-methylthiophene-3-carbonitrile and benzoyl isocyanate as a white solid. 1H NMR (400 MHz, DMSO-d6) δ2.36 (d, J=1.2 Hz, 3H), 6.89 (d, J=1.2 Hz, 1H), 7.55 (t, J=8.0 Hz, 2H), 7.66 (d, J=7.2 Hz, 1H), 8.03-8.01 (m, 2H), 11.60 (brs, 1H), 12.08 (bs, 1H). MS 286 (MH+).

Sources & evidence

ORD record
ord-5d25c90e84924c199e87f72d7d77db23
Source dataset
uspto-grants-2013_09
Patent number
US08541421B2

Linked notes

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