Pyridine → 3-(4-Fluorophenoxy)-alpha-cyanobenzyl alpha-cyclopropyl-4-chlorophenylacetate

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Reaction Steps

With stirring, 1 g of pyridine in 3 ml of toluene and 2.3 g of α-cyclopropyl-4-chlorophenylacetyl chloride in 3 ml of toluene are added successively at 0° to 10° C. to a solution of 2.43 g of 3-(4-fluorophenoxy)-α-cyanobenzyl alcohol in 20 ml of toluene. After stirring for 10 hours at room temperature, the reaction mixture is washed with water, 2 N hydrochloric acid and 3% sodium bicarbonate solution. The organic layer is dried over sodium sulfate and the toluene is distilled off, affording the compound of the formula ##STR4## with a refractive index of nD20 =1.5880.

Provenance & Evidence