Ethanol → 2-(5-Bromo-pyridin-3-yl)-N-methyl-acetamide

HRID 445764

Reaction equation

HRID 445764 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]([CH2:8][C:9]([OH:11])=O)[CH:5]=[N:6][CH:7]=1.[CH3:12][NH2:13].CCO>>[Br:1][C:2]1[CH:3]=[C:4]([CH2:8][C:9]([NH:13][CH3:12])=[O:11])[CH:5]=[N:6][CH:7]=1

Participants

4

Reactant 3

HCID 702EthanolHCID 6329MethylamineHCID 28025392-(5-Bromopyridin-3-yl)acetic acid

Product 1

HCID 542368122-(5-Bromo-pyridin-3-yl)-N-methyl-acetamide

Procedure

The title compound was synthesized in a similar manner as described for Example 103 using (5-bromo-pyridin-3-yl)-acetic acid (ABCR, Karlsruhe, Germany, 1.815 mmol) and 8 M methylamine in EtOH (Aldrich, Buchs, Switzerland, 7.26 mmol) to give the title compound as an off-white solid. (HPLC: tR 1.74 min (Method A); M+H=229, 231 MS-ES)

Workup

  1. customThe title compound was synthesized in a similar manner

Sources & evidence

ORD record
ord-2a07b27fc62142d5a8c6f5ad95515fb3
Source dataset
uspto-grants-2013_07
Patent number
US08476294B2

Linked notes

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