1-Methylpiperazine → Methyl 2-(4-methylpiperazino)-5-nitrobenzenecarboxylate

HRID 44644

Reaction equation

HRID 44644 reaction equation
F[C:2]1[CH:11]=[CH:10][C:9]([N+:12]([O-:14])=[O:13])=[CH:8][C:3]=1[C:4]([O:6][CH3:7])=[O:5].[CH3:15][N:16]1[CH2:21][CH2:20][NH:19][CH2:18][CH2:17]1>CO>[CH3:15][N:16]1[CH2:21][CH2:20][N:19]([C:2]2[CH:11]=[CH:10][C:9]([N+:12]([O-:14])=[O:13])=[CH:8][C:3]=2[C:4]([O:6][CH3:7])=[O:5])[CH2:18][CH2:17]1

Participants

4

Reactant 2

HCID 531671-MethylpiperazineHCID 11217860Methyl 2-Fluoro-5-nitrobenzoate

Product 1

HCID 36405266Methyl 2-(4-methylpiperazino)-5-nitrobenzenecarboxylate

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A solution of methyl 2-fluoro-5-nitro-benzoate (3.487 g, 17.511 mmol) and N-methylpiperazine (3.855 mL, 3.508 g, 35.022 mmol) in 30 mL of anhydrous methanol was heated to reflux for 5 hours.

Workup

  1. temperatureto reflux for 5 hours

Sources & evidence

ORD record
ord-36509e16039c4f43b53665e1858e6db9
Source dataset
uspto-grants-2013_09
Patent number
US08541429B2

Linked notes

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