Hydrochloric Acid → (6-Methylpyridin-2-yl)methanol hydrochloride

HRID 446815Notes

Reaction equation

HRID 446815 reaction equation
C([O:4][CH2:5][C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([CH3:12])[N:7]=1)(=O)C.[ClH:13]>>[ClH:13].[CH3:12][C:8]1[N:7]=[C:6]([CH2:5][OH:4])[CH:11]=[CH:10][CH:9]=1

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 291137(6-Methylpyridin-2-yl)methyl acetate

Product 1

HCID 18413908(6-Methylpyridin-2-yl)methanol hydrochloride

Procedure

A solution of (6-methylpyridin-2-yl)methyl acetate (1.0 g) in concentrated HCl (3 mL) was refluxed for 1 h. The reaction mixture was then concentrated in vacuo to obtain the crude product. The crude material was azeotroped with toluene, and the residue obtained was filtered and dried in vacuo to afford (6-methylpyridin-2-yl)methanol hydrochloride (811 mg) as a solid.

Workup

  1. concentrationThe reaction mixture was then concentrated in vacuo
  2. customto obtain the crude product
  3. customThe crude material was azeotroped with toluene
  4. customthe residue obtained
  5. filtrationwas filtered
  6. customdried in vacuo

Sources & evidence

ORD record
ord-fbf72e3296044ccb8ffa6a04d73dd71d
Source dataset
uspto-grants-2013_07
Patent number
US08481534B2

Reaction notes

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