Hydrochloric Acid → (2R)-2-amino-N,N-dimethylpropanamide hydrochloride
Reaction equation
C(OC(=O)[NH:7][C@@H:8]([C:10](=[O:14])[N:11]([CH3:13])[CH3:12])[CH3:9])(C)(C)C.[ClH:16]>O1CCOCC1>[ClH:16].[NH2:7][C@H:8]([CH3:9])[C:10]([N:11]([CH3:13])[CH3:12])=[O:14]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
((R)-1-Dimethylcarbamoyl-ethyl)-carbamic acid tert-butyl ester (1.1 g, 5.1 mmol) was dissolved in 26 mL of cold 4M HCl in dioxane. After 1.5 h the reaction was evaporated to provide (R)-2-amino-N,N-dimethyl-propionamide hydrochloride which was used without further purification.
Workup
- customAfter 1.5 h the reaction was evaporated
Sources & evidence
- ORD record
- ord-3f7e6a1103844b4395bf35bb14e51da2
- Source dataset
- uspto-grants-2013_07
- Patent number
- US08481541B2
Reaction notes
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