Potassium Carbonate → 4-Ethynyl-1-(4-fluorophenyl)-2-methyl-1H-imidazole

HRID 447177

Reaction equation

HRID 447177 reaction equation
COP(=O)OC.[C:7](=O)([O-])[O-].[K+].[K+].[F:13][C:14]1[CH:19]=[CH:18][C:17]([N:20]2[CH:24]=[C:23]([CH:25]=O)[N:22]=[C:21]2[CH3:27])=[CH:16][CH:15]=1>CO>[C:25]([C:23]1[N:22]=[C:21]([CH3:27])[N:20]([C:17]2[CH:18]=[CH:19][C:14]([F:13])=[CH:15][CH:16]=2)[CH:24]=1)#[CH:7]

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 13361Phosphonic acid, dimethyl esterHCID 859979931-(4-fluoro-phenyl)-2-methyl-1H-imidazole-4-carbaldehyde

Product 1

HCID 116655954-Ethynyl-1-(4-fluorophenyl)-2-methyl-1H-imidazole

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent2×

Procedure

Diazo-2-oxo-propyl)-phosphonic acid dimethyl ester is dissolved in methanol. Potassium carbonate is added. A solution of 1-(4-fluoro-phenyl)-2-methyl-1H-imidazole-4-carbaldehyde in methanol is added dropwise at room temperature. The reaction mixture is stirred at room temperature overnight. The desired compound 4-ethynyl-1-(4-fluoro-phenyl)-2-methyl-1H-imidazole is obtained.

Sources & evidence

ORD record
ord-2f1b4f744d2248d684a24dff5e47aa12
Source dataset
uspto-grants-2013_07
Patent number
US08481548B2

Linked notes

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