HCID 519042, compound → 1-(2-methylthiazol-5-yl)ethanone
Reaction equation
Br[C:2](=[C:6]([OH:8])[CH3:7])[C:3](=O)C.[C:9]([NH2:12])(=[S:11])[CH3:10]>CC(C)=O>[C:6]([C:2]1[S:11][C:9]([CH3:10])=[N:12][CH:3]=1)(=[O:8])[CH3:7]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
To a solution of the product of Example 151B (14.5 g, 88 mmol) in acetone (220 mL) was added thioacetamide (6.6 g, 88 mmol) and stirred overnight. The solid was filtered to give the title compound as the hydrogen bromide salt. 1H NMR (300 MHz, DMSO-d6) δ ppm 2.54 (s, 3 H) 2.71 (s, 3 H) 8.46 (s, 1 H). MS (DCI) m/z 142 (M+H)+.
Workup
- filtrationThe solid was filtered
Sources & evidence
- ORD record
- ord-7ce2d9ad574a4beea8cdfbe631fa4f0f
- Source dataset
- uspto-grants-2013_07
- Patent number
- US08481574B2
Reaction notes
Loading…