Dichloromethane → HCID 57171531, compound

HRID 449118

Reaction equation

HRID 449118 reaction equation
[CH2:1]([C:3]1[CH:4]=[C:5]([OH:10])[CH:6]=[CH:7][C:8]=1[Cl:9])[CH3:2].[C:11]1(B(O)O)[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1.C(Cl)Cl>>[Cl:9][C:8]1[CH:7]=[CH:6][C:5]([O:10][C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)=[CH:4][C:3]=1[CH2:1][CH3:2]

Participants

4

Reactant 3

HCID 6344DichloromethaneHCID 66827Phenylboronic AcidHCID 842234-Chloro-3-ethylphenol

Product 1

HCID 57171531HCID 57171531, compound

Procedure

3-ethyl-4-chlorophenol (2.0 g, 0.013 mol), phenylboronic acid (4.7 g, 0.038 mol), TEA (11 mL, 0.077 mol), cupric acetate (4.2 g, 0.023 mol) and DCM (60 mL, 0.9 mol) were added to a 100 mL oven dried flask and the reaction was stirred at rt for 24 h. The solvent was then removed under reduced pressure and the resulting residue was purified by flash chromatography (5% EtOAc in Hexane).

Workup

  1. customdried flask
  2. customThe solvent was then removed under reduced pressure
  3. customthe resulting residue was purified by flash chromatography (5% EtOAc in Hexane)

Sources & evidence

ORD record
ord-468ee86025da4a8694d036ab3c535b72
Source dataset
uspto-grants-2013_07
Patent number
US08481733B2

Linked notes

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