Ammonia → 2,4-Dichloro-5-fluoro-3-nitrobenzamide

HRID 450329

Reaction equation

HRID 450329 reaction equation
[NH3:1].[Cl:2][C:3]1[C:11]([N+:12]([O-:14])=[O:13])=[C:10]([Cl:15])[C:9]([F:16])=[CH:8][C:4]=1[C:5](Cl)=[O:6]>C1COCC1>[Cl:2][C:3]1[C:11]([N+:12]([O-:14])=[O:13])=[C:10]([Cl:15])[C:9]([F:16])=[CH:8][C:4]=1[C:5]([NH2:1])=[O:6]

Participants

4

Reactant 2

HCID 222AmmoniaHCID 11818130Benzoyl chloride, 2,4-dichloro-5-fluoro-3-nitro-

Product 1

HCID 866744942,4-Dichloro-5-fluoro-3-nitrobenzamide

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

32%-aq. NH3-solution (250 mL) is dropped to 2,4-dichloro-5-fluoro-3 nitro-benzoic acid chloride (16.0 g, 59 mmol) in 100 mL THF and it is stirred for 20 min. Then the mixture is concentrated and the resulting precipitate is collected and dried.

Workup

  1. concentrationThen the mixture is concentrated
  2. customthe resulting precipitate is collected
  3. customdried

Sources & evidence

ORD record
ord-df08f57c65574d2dac6a5cf4ec7a4982
Source dataset
uspto-grants-2013_07
Patent number
US08486968B2

Linked notes

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