Ammonia → 5-(Pyrazin-2-yl)-3-(pyridin-3-yl)-1,2,4-oxadiazole

HRID 450602

Reaction equation

HRID 450602 reaction equation
[OH:1][N:2]=[C:3]([NH2:10])[C:4]1[CH:9]=[CH:8][CH:7]=[N:6][CH:5]=1.[N:11]1[CH:16]=[CH:15][N:14]=[CH:13][C:12]=1[C:17](O)=O.N>>[N:11]1[CH:16]=[CH:15][N:14]=[CH:13][C:12]=1[C:17]1[O:1][N:2]=[C:3]([C:4]2[CH:5]=[N:6][CH:7]=[CH:8][CH:9]=2)[N:10]=1

Participants

4

Reactant 3

HCID 222AmmoniaHCID 10472-Pyrazinecarboxylic acidHCID 308113N-Hydroxynicotinimidamide

Product 1

HCID 164184615-(Pyrazin-2-yl)-3-(pyridin-3-yl)-1,2,4-oxadiazole

Procedure

The titled compound was prepared according to the procedure of Example 8 using N′-hydroxynicotinimidamide (Aldrich) and pyrazine-2-carboxylic acid (Aldrich). 1H NMR (300 MHz, CD3OD) δ 7.66 (ddd, J=8.0, 4.9, 1.0 Hz, 1 H), 8.60 (dt, J=8.0, 1.9 Hz, 1 H), 8.77 (dd, J=5.0, 1.8 Hz, 1 H), 8.86-8.89 (m, 1 H), 8.89-8.91 (m, 1 H), 9.34 (dd, J=2.4, 0.8 Hz, 1H), 9.56 (d, J=1.6 Hz, 1 H) ppm; MS (DCI/NH3) m/z 226 (M+H)+.

Sources & evidence

ORD record
ord-8ae5f3fd252a419398ad3fed739ace43
Source dataset
uspto-grants-2013_07
Patent number
US08486979B2

Linked notes

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