Hydrochloric Acid → 1H-pyrrolo[2,3-b]pyridine-4-carboxylic acid
Reaction equation
C([N:4]1[C:8]2[N:9]=[CH:10][CH:11]=C(C#N)[C:7]=2[CH:6]=[CH:5]1)(=O)C.[OH-:15].[Na+].[CH2:17]([OH:19])[CH3:18].Cl>O>[NH:4]1[C:8]2[N:9]=[CH:10][CH:11]=[C:18]([C:17]([OH:15])=[O:19])[C:7]=2[CH:6]=[CH:5]1Participants
6
Conditions
- Temperature
- 90 °C
Procedure
A mixture of 1-acetyl-1H-pyrrolo[2,3-b]pyridine-4-carbonitrile (1.80 g, 11.10 mmol), 2 M aqueous sodium hydroxide solution (25 mL) and ethanol (25 mL) was stirred at 90° C. for 16 hr. The reaction mixture was neutralized with hydrochloric acid and diluted with water. The precipitate was collected by filtration, and washed with water and diethyl ether to give the title compound (1.51 g, yield 84%) as pale-yellow crystals.
Workup
- filtrationThe precipitate was collected by filtration
- washwashed with water and diethyl ether
Sources & evidence
- ORD record
- ord-0225558ae596489fab4eb4960642631b
- Source dataset
- uspto-grants-2013_07
- Patent number
- US08492378B2
Reaction notes
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