HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → Metformin Hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | HCID 178484382 | HCID 178484382 | — |
| Solvent | Acetone | HCID 180 | — |
| Product | Metformin Hydrochloride | HCID 14219 | 76.4% |
Reaction Steps
500 mg of metformin free base was dissolved in 30 Ml of acetone, and then 280 Ml of concentrated hydrochloric acid was added, and stirred for 2 hours at room temperature. The resulting crystal was filtered and washed with acetone, and then dried with heated air at 70° C. to obtain 490 mg of metformin hydrochloride (yield: 76.4%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08541474B2 |
| Source dataset | uspto-grants-2013_09 |
| ORD ID | ord-bb7f28c0f0144c43ad84ff9519be4688 |
| Source note | uspto-grants-2013_09 |