反应详情

500 mg of metformin free base was dissolved in 30 Ml of acetone, and then 280 Ml of concentrated hydrochloric acid was added, and stirred for 2 hours at room temperature. The resulting crystal was filtered and washed with acetone, and then dried with heated air at 70° C. to obtain 490 mg of metformin hydrochloride (yield: 76.4%).

1. filtrationThe resulting crystal was filtered
2. washwashed with acetone
3. customdried
4. temperaturewith heated air at 70° C.