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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 4546Generated: October 25, 2026

N-(2-Chloroethyl)dibenzylamine → 3-(2-Dibenzylaminoethoxy)salicylic acid methyl ester

https://huagongshe.com/reaction/4546

Reaction equation

Participants

RoleNameHCIDCharge
ReactantN-(2-Chloroethyl)dibenzylamineHCID 5820—
ReactantPotassium CarbonateHCID 11430—
ReactantMethyl 2,3-DihydroxybenzoateHCID 75484—
SolventAcetonitrileHCID 6342—
Product3-(2-Dibenzylaminoethoxy)salicylic acid methyl esterHCID 53929446—

Reaction Steps

2,3-dihydroxybenzoic acid methyl ester is reacted in the presence of potassium carbonate in acetonitrile with 1.1 equivalents of 1-dibenzylamino-2-chloroethane for 18 hours at 82°. The crude 3-(2-dibenzylaminoethoxy)salicyclic acid methyl ester obtained after working up is put to further use without further purification.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS04727067
Source datasetuspto-grants-1988_02
ORD IDord-bdd53f2aa794405982b767a086f662bc
Source noteuspto-grants-1988_02