4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole → 3-Phenyl-2-[3-(1H-pyrazol-4-yl)-phenyl]-propionitrile

HRID 45484

Reaction equation

HRID 45484 reaction equation
Br[C:2]1[CH:3]=[C:4]([CH:8]([CH2:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[C:9]#[N:10])[CH:5]=[CH:6][CH:7]=1.CC1(C)C(C)(C)OB([C:26]2[CH:27]=[N:28][NH:29][CH:30]=2)O1>>[C:12]1([CH2:11][CH:8]([C:4]2[CH:5]=[CH:6][CH:7]=[C:2]([C:26]3[CH:27]=[N:28][NH:29][CH:30]=3)[CH:3]=2)[C:9]#[N:10])[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1

Participants

3

Reactant 2

HCID 27740104-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazoleHCID 593319812-(3-Bromo-phenyl)-3-phenyl-propionitrile

Product 1

HCID 113002733-Phenyl-2-[3-(1H-pyrazol-4-yl)-phenyl]-propionitrile

Procedure

2-(3-Bromo-phenyl)-3-phenyl-propionitrile was reacted with 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole following the procedure set out in Example 1 to give the title compound. (LC/MS: (PS-A) Rt 2.98 [M+H]+ 274).

Sources & evidence

ORD record
ord-c2e1cfad42664f9293490ffbe313de99
Source dataset
uspto-grants-2013_09
Patent number
US08541461B2

Linked notes

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