Sulfamide → HCID 11379214, compound
Reaction equation
[O:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[O:3][CH:2]1[CH2:10][NH2:11].[S:12](N)([NH2:15])(=[O:14])=[O:13]>O1CCOCC1>[O:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[O:3][CH:2]1[CH2:10][NH:11][S:12]([NH2:15])(=[O:14])=[O:13]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
C-Benzo[1,3]dioxol-2-yl-methylamine (2.94 g, 19.4 mmol) and sulfamide (3.74 g, 38.9 mmol) were combined in dry dioxane (50 mL) and the solution was heated to reflux overnight. The reaction was concentrated and the residue was chromatographed (2% to 10% acetone in dichloromethane) to yield the title compound as a white solid.
Workup
- temperaturethe solution was heated
- temperatureto reflux overnight
- concentrationThe reaction was concentrated
- customthe residue was chromatographed (2% to 10% acetone in dichloromethane)
Sources & evidence
- ORD record
- ord-daaee8a9d99d45558e50973a824e5c29
- Source dataset
- uspto-grants-2013_07
- Patent number
- US08497298B2
Reaction notes
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