Potassium Cyanide → 2-(2,3-Dihydro-1,4-benzodioxin-2-yl)acetonitrile

HRID 455535

Reaction equation

HRID 455535 reaction equation
[C-:1]#[N:2].[K+].Br[CH2:5][CH:6]1[O:11][C:10]2[CH:12]=[CH:13][CH:14]=[CH:15][C:9]=2[O:8][CH2:7]1>CS(C)=O.O>[C:1]([CH2:5][CH:6]1[O:11][C:10]2[CH:12]=[CH:13][CH:14]=[CH:15][C:9]=2[O:8][CH2:7]1)#[N:2]

Participants

5

Reactant 2

HCID 9032Potassium CyanideHCID 983332-Bromomethyl-1,4-benzodioxane

Product 1

HCID 2675312-(2,3-Dihydro-1,4-benzodioxin-2-yl)acetonitrile

Reagents, catalysts & solvents 2

HCID 679Dimethyl SulfoxideSolventHCID 962WaterSolvent

Procedure

Potassium cyanide (2.05 g, 31.5 mmol) was added to 2-bromomethyl-(2,3 dihydrobenzo[1,4]dioxine) (6.87 g, 30 mmol) in DMSO (90 mL) and stirred at ambient temperature for 20 h. The reaction mixture was then diluted with water (250 mL) and extracted twice with diethyl ether. The diethyl ether was washed with water, then washed twice with brine, dried (Na2SO4) and evaporated in vacuo to yield 2-cyanomethyl-(2,3 dihydrobenzo[1,4]dioxine) as a white solid.

Workup

  1. extractionextracted twice with diethyl ether
  2. washThe diethyl ether was washed with water
  3. washwashed twice with brine
  4. dry with materialdried (Na2SO4)
  5. customevaporated in vacuo

Sources & evidence

ORD record
ord-21f41a6878e248b4a2132810be251508
Source dataset
uspto-grants-2013_07
Patent number
US08497298B2

Linked notes

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