Ethanol → Ethyl 3-bromo-4-methoxyphenylacetate

HRID 456212

Reaction equation

HRID 456212 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]([CH2:10][C:11]([OH:13])=[O:12])[CH:5]=[CH:6][C:7]=1[O:8][CH3:9].[CH3:14][CH2:15]O>Cl>[CH2:14]([O:12][C:11](=[O:13])[CH2:10][C:4]1[CH:5]=[CH:6][C:7]([O:8][CH3:9])=[C:2]([Br:1])[CH:3]=1)[CH3:15]

Participants

4

Reactant 2

HCID 702EthanolHCID 1366153-Bromo-4-methoxyphenylacetic acid

Product 1

HCID 57419861Ethyl 3-bromo-4-methoxyphenylacetate

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidCatalyst

Procedure

A solution of 3-bromo-4-methoxyphenylacetic acid (4.1 g, 16.7 mmol) and concentrated hydrogen chloride (2 drops) in EtOH (100 mL) were stirred at 80° C. for 3 days. After cooling to room temperature, the mixture was concentrated to dryness to give the title compound.

Workup

  1. concentrationthe mixture was concentrated to dryness

Sources & evidence

ORD record
ord-40154bfaaa5f406ca5094da0897e0562
Source dataset
uspto-grants-2013_07
Patent number
US08497381B2

Linked notes

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