Methylamine → 3-hydroxy-N-methylbenzamide
Reaction equation
[OH:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][CH:10]=1)[C:5](O)=[O:6].[CH3:11][NH2:12]>>[OH:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][CH:10]=1)[C:5]([NH:12][CH3:11])=[O:6]Participants
3
Procedure
A mixture of 3-hydroxybenzoic acid (1.3 g, 9.4 mmol) and a ethanolic methylamine solution (33%, 1.5 ml, 12.1 mmol) were stirred at 60° C. for 48 h, then the solvent was evaporated in vacuo, and the residue redissolved in a small volume of ethanol. The product precipitated from the solution by the addition of ethyl acetate. The precipitate was collected by filtration and dried to give the subtitled compound (1.3 g, 91%).
Workup
- customthe solvent was evaporated in vacuo
- dissolutionthe residue redissolved in a small volume of ethanol
- customThe product precipitated from the solution by the addition of ethyl acetate
- filtrationThe precipitate was collected by filtration
- customdried
Sources & evidence
- ORD record
- ord-0a298d99e03a41c588c18607c8b057ee
- Source dataset
- uspto-grants-2007_03
- Patent number
- US07186718B2
Reaction notes
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