HCID 68441993, compound → Methyl 2-oxo-2,3-dihydro-1h-pyrido[2,3-b][1,4]thiazine-7-carboxylate
Reaction equation
[CH3:1][O:2][C:3](=[O:19])[C:4]1[CH:9]=[C:8]([N+:10]([O-])=O)[C:7]([S:13][CH2:14][C:15](OC)=[O:16])=[N:6][CH:5]=1>C(O)(=O)C.[Fe]>[CH3:1][O:2][C:3]([C:4]1[CH:5]=[N:6][C:7]2[S:13][CH2:14][C:15](=[O:16])[NH:10][C:8]=2[CH:9]=1)=[O:19]Participants
4
Reactant 1
Product 1
Reagents, catalysts & solvents 2
Conditions
- Temperature
- 60 °C
Procedure
The ester (a) (1.0 g) in acetic acid (50 ml) was treated with iron powder (10 g) and the mixture was stirred and heated at 60° C. for 1 hour, cooled and filtered. The filtrate was evaporated, treated with sodium bicarbonate solution and extracted with warm chloroform. It was dried over sodium sulfate and evaporated to give a white solid (0.85 g).
Workup
- temperaturecooled
- filtrationfiltered
- customThe filtrate was evaporated
- additiontreated with sodium bicarbonate solution
- extractionextracted with warm chloroform
- dry with materialIt was dried over sodium sulfate
- customevaporated
Sources & evidence
- ORD record
- ord-40ea03c65f9f4d03acbf62fd64876745
- Source dataset
- uspto-grants-2007_03
- Patent number
- US07186730B2
Reaction notes
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