HomeMCPWorkbenchSkills
HomeWorkbenchNotificationsMe
llms.txt · MCP GuidePrivacy Policy · Terms of Service · Supportv1.8.0
  1. Home
  2. /Reaction

3-Butyn-1-OL → 2-Chloro-N-(1-hydroxy-cycloheptylmethyl)-5-[5-(2-hydroxy-ethyl)-isoxazol-3-yl]-benzamide

HRID 456890
Notes
Print preview

Reaction equation

HRID 456890 reaction equation
[Cl:1][C:2]1[CH:19]=[CH:18][C:17]([CH:20]=[N:21][OH:22])=[CH:16][C:3]=1[C:4]([NH:6][CH2:7][C:8]1([OH:15])[CH2:14][CH2:13][CH2:12][CH2:11][CH2:10][CH2:9]1)=[O:5].[CH2:23]([OH:27])[CH2:24][C:25]#[CH:26].Cl[O-].[Na+]>C(N(CC)CC)C.ClCCl.O>[Cl:1][C:2]1[CH:19]=[CH:18][C:17]([C:20]2[CH:26]=[C:25]([CH2:24][CH2:23][OH:27])[O:22][N:21]=2)=[CH:16][C:3]=1[C:4]([NH:6][CH2:7][C:8]1([OH:15])[CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14]1)=[O:5]
ParticipantsProcedureWorkupSources & evidenceReaction notes

Participants

7

Reactant 3

HCID 135663-Butyn-1-OLHCID 23665760Sodium HypochloriteHCID 724346312-Chloro-N-(1-hydroxy-cycloheptylmethyl)-5-(hydroxyimino-methyl)-benzamide

Product 1

HCID 588181972-Chloro-N-(1-hydroxy-cycloheptylmethyl)-5-[5-(2-hydroxy-ethyl)-isoxazol-3-yl]-benzamideYield 22.1%

Reagents, catalysts & solvents 3

HCID 8471
Triethylamine
Catalyst
HCID 962WaterSolvent
HCID 6344DichloromethaneSolvent

Procedure

A mixture of 2-chloro-N-(1-hydroxy-cycloheptylmethyl)-5-(hydroxyimino-methyl)-benzamide (50 mg, 0.15 mmol), but-3-yn-1-ol (27 mg, 0.38 mmol), sodium hypochlorite (1 mL, 4%) and triethylamine (2 drops) in dichloromethane (2 mL) was stirred at room temperature for 5 d. The mixture was diluted with water and extracted with ethyl acetate. The combined organic layers were washed with water, and brine, dried over sodium sulfate, filtered and adsorbed onto silica gel. The residue was purified by flash column chromatography (65% ethyl acetate-hexanes) to afford the title compound (13 mg).

Workup

  1. extractionextracted with ethyl acetate
  2. washThe combined organic layers were washed with water, and brine
  3. dry with materialdried over sodium sulfate
  4. filtrationfiltered
  5. customThe residue was purified by flash column chromatography (65% ethyl acetate-hexanes)

Sources & evidence

ORD record
ord-2c97d1b225fe4cfaab4450f4f3046fa1
Source dataset
uspto-grants-2007_03
DOI
10.6084/m9.figshare.5104873.v1
Patent number
US07186742B2

Reaction notes

Loading…

On this pageParticipantsProcedureWorkupSources & evidenceReaction notes