Hydrazine hydrate (1:1) → 3-isopropyl-1H-pyrazol-5(4H)-one
Reaction equation
O.[NH2:2][NH2:3].[C:4]([CH2:9][C:10]([O:12]CC)=O)(=O)[CH:5]([CH3:7])[CH3:6]>C(O)C>[CH:5]([C:4]1[CH2:9][C:10](=[O:12])[NH:2][N:3]=1)([CH3:7])[CH3:6]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 22.5 °C
Procedure
70 g (1.26 mol) of hydrazine hydrate were added dropwise at 10 to 30° C. to a solution of 100 g (0.62 mol) of ethyl isobutyrylacetate in 60 ml of ethanol. After the exothermic reaction had subsided, the mixture was stirred at 20 to 25° C. for a further 14 hours approximately and was then cooled to approximately −10° C. 52 g of the title compound were isolated by filtration.
Workup
- customAfter the exothermic reaction
- temperaturewas then cooled to approximately −10° C
Sources & evidence
- ORD record
- ord-da45a32bb11c40cdadadff6e0878b48b
- Source dataset
- uspto-grants-2007_03
- Patent number
- US07186861B2
Reaction notes
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