Cyclohexanepropanoic acid → HCID 178526602, compound

HRID 458960

Reaction equation

HRID 458960 reaction equation
[CH:1]1([CH2:7]CC(O)=O)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[N+:12]([C:15]1[CH:16]=[C:17]([CH:22]=[CH:23][CH:24]=1)C(=O)CBr)([O-:14])=[O:13].C(O[C:30]([NH:32][CH2:33][C:34](O)=O)=O)(C)(C)C.[N:37]([C:40]1C=CC(C(=O)CBr)=CC=1)=[N+]=[N-]>>[CH:1]1([CH2:7][CH2:34][C:33]2[NH:37][CH:40]=[C:30]([C:23]3[CH:22]=[CH:17][CH:16]=[C:15]([N+:12]([O-:14])=[O:13])[CH:24]=3)[N:32]=2)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]1

Participants

5

Reactant 4

HCID 69702Cyclohexanepropanoic acidHCID 752132-Bromo-1-(3-nitrophenyl)ethan-1-oneHCID 78288N-(tert-butoxycarbonyl)glycineHCID 926274-Azidophenacyl bromide

Product 1

HCID 178526602HCID 178526602, compoundYield 26%

Procedure

This compound is prepared according to an operating method analogous to that described for Stage 4.1 of Example 4, with cyclohexylethylcarboxylic acid and 3-nitrophenacyl bromide placing N-(tert-butoxycarbonyl)-glycine and 4-azidophenacyl bromide respectively. The expected compound is obtained in the form of a yellow powder with a yield of 26%.

Workup

  1. customThis compound is prepared

Sources & evidence

ORD record
ord-888ec7bdd9894376a72ebe9c688b6941
Source dataset
uspto-grants-2007_03
Patent number
US07192975B2

Linked notes

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