Potassium Carbonate → HCID 178439142, compound

HRID 45940

Reaction equation

HRID 45940 reaction equation
[N:1]1[C:5]2[CH:6]=[CH:7][C:8]([NH2:10])=[CH:9][C:4]=2[NH:3][CH:2]=1.[CH:11]([C:14]1[CH:21]=[CH:20][C:17]([CH2:18]Br)=[CH:16][CH:15]=1)([CH3:13])[CH3:12].C([O-])([O-])=O.[K+].[K+]>>[CH:11]([C:14]1[CH:21]=[CH:20][C:17]([CH2:18][N:10]([CH2:18][C:17]2[CH:20]=[CH:21][C:14]([CH:11]([CH3:13])[CH3:12])=[CH:15][CH:16]=2)[C:8]2[CH:7]=[CH:6][C:5]3[NH:1][CH:2]=[N:3][C:4]=3[CH:9]=2)=[CH:16][CH:15]=1)([CH3:13])[CH3:12]

Participants

4

Reactant 3

HCID 11430Potassium CarbonateHCID 136235-AminobenzimidazoleHCID 477191-(Bromomethyl)-4-(propan-2-yl)benzene

Product 1

HCID 178439142HCID 178439142, compound

Procedure

The compound was synthesized starting from benzimidazol-5-amine (133 mg; 1 mmol; 1 eq.), 4-isopropylbenzylbromide (469 mg; 0.376 ml; 2.2 mmol; 2.2 eq.) and K2CO3 (304 mg; 2.2 mmol; 2.2 eq.) according to method 5; Yield: 0.147 g (36.9%); MS m/z: 398.4 [M+H]+; 1H-NMR (500 MHz, DMSO d6): δ 1.16 (d, 12H, 3J=7.0 Hz); 2.83 (hept, 2H, 3J=7.0 Hz); 4.62 (s, 4H); 6.69 (br s, 1H); 6.73 (dd, 1H, 4J=2.4 Hz, 3J=8.9 Hz); 7.16-7.20 (m, 8H); 7.32 (d, 1H, 3J=8.9 Hz); 7.89 (s, 1H); 11.90 (br s, 1H); HPLC (METHOD [A]): rt 19.95 min (94.4%)

Workup

  1. customThe compound was synthesized
  2. customrt 19.95 min (94.4%)

Sources & evidence

ORD record
ord-d1a7beb543444b07bcb601cf4aa26218
Source dataset
uspto-grants-2013_09
Patent number
US08541596B2

Linked notes

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